Nomifensine: effect in Parkinsonian patients not receiving levodopa.
نویسندگان
چکیده
A clinical trial using the anti-depressant nomifensine in Parkinsonism is reported. Eighteen subjects not receiving levodopa participated. The drug had a small, but significant anti-Parkinsonian effect. No troublesome side effects were encountered. In the treatment of Parkinsonism, nomifensine may be considered as an alternative to amantadine or anticholinergics, especially where depression is an added feature.
منابع مشابه
Nomifensine in parkinsonism.
Nomifensine, a tetrahydroisoquinolone antidepressant which facilitates dopaminergic and noradrenergic transmission, was studied in 28 Parkinsonism patients most of whom were also receiving conventional medications. Double-blind evaluations revealed a moderate therapeutic action at a mean dose level of 150 mg daily. Adverse reactions were encountered, similar to those identical by levodopa.
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ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 44 4 شماره
صفحات -
تاریخ انتشار 1981